Seungjun "Jason" Lee, Ph.D.

Postdoctoral Fellow

Research

Jason's project focuses on imaging the overproduction of reactive oxygen species (ROS) in living subject which is implicated in the development of numerous diseases. ROS is byproduct of cell metabolism. In normal situation, most of ROS is scavenged by cellular antioxidants. Overproduction of ROS is induced by food, chemicals, smoke, stress or disease, such as diabetes, Alzheimer, or inflammatory bowel disease. The early detection of the overproduction of ROS is important for prevention and diagnosis of these diseases. He is using hydro-cyanine dyes to localize and quantify the overproduction of ROS in inflammatory disease animal models.

Education/Background

Jason earned his bachelors in industrial chemistry from the Hanyang University, Seoul, Korea in 1996. He majored in biomedical engineering at the graduate school of the same university for his master’s degree. Following graduation, Jason worked in the Biomaterials Laboratory in St. Mary Hospital Institute of Biomedical Science, Seoul, Korea as an assistant researcher. He earned his doctoral degree in bioengineering from the Pennsylvania State University in 2004. After graduation, he worked in the Cellular and Molecular Physiology Department in Louisiana State University in Shreveport as a post doctoral fellow until December 2008.

Lee S, Carter PR, Watts MN, Bao JR, and Harris NR. Effects of the endothelin-converting enzyme inhibitor SM-19712 in a mouse model of dextran sodium sulfate-induced colitis. Inflammatory Bowel Disease (2009)

Lee S, Morgan GA, and Harris NR. Ozagrel reverses streptozotocin-induced constriction of arterioles in rat retina. Microvascular Research, 76 (2008) 217-223

Lee S and Harris NR. Losartan and ozagrel reverse retinal arteriolar constriction in non-obese diabetic mice. Microcirculation, 15 (2008) 379-387

Langford MP, Redens TB, Harris NR, Lee S, Jain SK, Reddy S, and McVie R. Plasma levels of cell-free apoptotic DNA ladders and gamma-glutamyltranspeptidase (GGT) in diabetic children. Experimental Biology and Medicine, 232 (2007) 1160-1169

Snyder B, Lee S, Newnham RE, and Smith NB. Ferroelectric transducer arrays for transdermal insulin delivery. Journal of Materials Science, 41 (2006) 211-216

Lee S, Nayak V, Dodds J, Pishko M and Smith NB. Glucose measurements with sensors and ultrasound. Ultrasound in Med & Biol, 31 (2005) 971-977

Lee S, Smith NB, Markley D, Snyder B, Uzgur AE, Pishko M, and Newnham RE. Composite transducer arrays for the treatment of diabetes. Int. J. Appl. Ceram. Technol., 2 (2005) 308-316

Lee S, Snyder B, Newnham RE, and Smith NB. Noninvasive ultrasonic transdermal insulin delivery in rabbits using the light-weight cymbal array. Diabetes Technology & Therapeutics, 6 (2004) 808-815

Lee S, Newnham RE, and Smith NB. Short ultrasound exposure times for noninvasive insulin delivery in rats using the light weight cymbal array. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 51 (2004) 176-180

Smith NB, Lee S, and Shung KK. Ultrasound Mediated Transdermal in vivo Transport of Insulin with Low Profile Cymbal Arrays. Ultrasound in Med & Biol, 29 (2003) 1205-1210

Smith NB, Lee S, Maione E, Roy RB, McElligott S, and Shung KK. Ultrasound-mediated transdermal transport of insulin in vitro through human skin using novel transducer designs. Ultrasound in Med & Biol, 29 (2003) 311-317

Hong SR, Lee S, Shim JW, and Lee YM. Study on gelatin-containing artificial skin IV: A comparative study on the effect of antibiotic and EGF on cell proliferation during epidermal healing. Biomaterials, 22 (2001) 2777-2783

Lee S, Kim SS, and Lee YM. Interpenetrating polymer network hydrogels based on poly (ethylene glycol) macromer and chitosan. Carbohydrate polymer, 41 (2000) 197-205

Publications

Presentations

Lee S and Harris NR. Venule-mediated arteriolar constriction in the NOD mouse retina. Experimental Biology Annual Meeting, Washington, DC, May 2007

Lee S, Morgan GA, and Harris NR. Venule-mediated arteriolar constriction in the diabetic rat retina. Experimental Biology Annual Meeting, San Francisco, CA, April 2006

Lee S, Newnham RE, Pishko M, and Smith NB. Noninvasive ultrasound glucose monitoring and insulin delivery using the low-profile cymbal array. 4th Annual Diabetes Technology Meeting, Philadelphia, PA, October 2004

Lee S, Snyder B, Meyer R, Nayak V, Markley DC, Newnham RE, and Smith NB. Noninvasive ultrasonic transdermal insulin delivery in rabbits using the light weight cymbal array. IEEE International Ultrasonics Symposium, Honolulu, HI, October 2003

Lee S, Newnham RE, and Smith NB. Short ultrasound exposure times for noninvasive insulin delivery in rats using the light weight cymbal array. 3rd International Symposium on Therapeutic Ultrasound, Lyon, France, June 2003

Lee S, Smith NB, and Newnham RE. Needle free ultrasonic insulin patch for diabetic patient. 8th Annual Graduate Exhibition, University Park, PA. March 2003

Lee S, Smith NB, and Shung KK. Ultrasound mediated transdermal in vivo transport of insulin with low profile cymbal arrays. IEEE Ultrasonics Symposium, Munich, Germany, October 2002

McElliott S, Redding BK, Menon GK, Roy RB, Shung KK, Smith NB, Lee S, and Inzucchi S. Ultrasonic transdermal insulin delivery. American Diabetes Association 61st Scientific Session, Philadelphia, PA, June 2001

Lee S, Kim SS, and Lee YM. Interpenetrating polymer network hydrogels based on poly(ethylene glycol) macromer and chitosan. Biannual Meeting of the Korea Society of Industrial Chemistry, Jeonju, Korea, April 1996

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