Standley SM, Kwon YJ, Murthy N, Kunisawa J, Shastri N, Guillaudeu SJ, Lau L, Fréchet JMJ. "Acid-degradable particles for protein-based vaccines: Enhanced survival rate for tumor-challenged mice using ovalbumin model". Bioconj. Chem. (2004), 15(6), 1281-1288.

Goh SL, Murthy N, Xu M, Frechet JMJ. "Cross-linked microparticles as carriers for the delivery of plasmid DNA for vaccine development". Bioconj. Chem. (2004), 15(3), 467-474.

Bulmus V, Woodward M, Lianne L, Murthy N, Stayton P, Hoffman A. "A new pH-responsive and glutathione-reactive, endosomal membrane-disruptive polymeric carrier for intracellular delivery of biomolecular drugs". J. Control. Release. (2003), 93(2), 105-120.

Murthy N, Xu M, Schuck S, Kunisawa J, Shastri N, Fréchet JMJ. "A new delivery vehicle for protein based vaccines: Acid degradable protein loaded microgels". Proc. Natl. Acad. Sci. (2003), 100(9), 4995-5000.

Murthy N, Campbell J, Fausto N, Hoffman AS, Stayton PS. "Bioinspired pH-responsive polymers for the intracellular delivery of biomolecular drugs". Bioconj. Chem. (2003), 14(2), 412-419.

Murthy N, Campbell J, Fausto N, Hoffman A, Stayton S. "pH responsive polymeric carriers that target uptake and enhance the intracellular delivery of oligonucleotides". J. Control. Release. (2003), 89(3), 365-374.

Murthy N, Thng Y, Schuck S, Xu M, Fréchet JMJ. "A novel strategy for encapsulation and release of proteins: hydrogels and microgels with acid-labile acetal crosslinkers". J. Am. Chem. Soc. (2002), 124(42), 12398-12399.

Kyriakides TR, Cheung C, Murthy N, Bornstein P, Stayton PS, Hoffman AS. "pH-sensitive polymers that enhance intracellular drug delivery in vivo". J. Control. Release. (2002), 78(1-3), 295-303.

Hoffman AS, Stayton PS, Press O, Murthy N, Lackey AC, Cheung C, Black F, Campbell J, Fausto N, Kyriakides TR, Bornstein P. "Design of smart polymers that can direct intracellular drug delivery. Polymers for Advanced Technologies. (2002), 13(10-12), 992-999.

Cheung C, Murthy N, Stayton P, Hoffman A. "A pH-sensitive polymer that enhances cationic lipid-mediated gene transfer". Bioconj. Chem. (2001), 12(6), 906-91.

Hoffman AS, Stayton PS, Press O, Murthy N, Lackey C, Cheung C, Black F, Campbell J, Fausto N, Kyriakides TR, Bornstein P. "Bio-inspired polymers that control intracellular drug delivery". Biotechnol. Bioprocess. Eng. (2001), 6(4), 205-212.

Murthy N, Chang I, Stayton P, Hoffman A. "pH-sensitive hemolysis by random copolymers of alkyl acrylates and acrylic acid". Macromol Symp. (2001), 172(1) (Polymers in Medicine), 49-55.

Mourad PD, Murthy N, Porter T, Poliachik SL, Crum L, Hoffman AS, Stayton PS. "Focused ultrasound and poly(2-ethylacrylic acid) act synergistically to disrupt lipid bilayers in vitro". Macromolecules. (2001), 34(8), 2400-2401.

Stayton PS, Hoffman AS, Murthy N, Lackey C, Cheung C, Tan P, Klumb LA, Chilkoti A, Wilbur FS, Press OW. "Molecular engineering of proteins and polymers for targeting and intracellular delivery of therapeutics". J. Control. Release. (2000), 65(1-2), 203-220.

Murthy N, Robichaud J, Tirrell DA, Stayton PS, Hoffman AS. "The design and synthesis of polymers for eukaryotic membrane disruption". J. Control. Release. (1999), 61(1-2), 137-143.

Lackey C, Murthy N, Press OW, Tirrell DA, Hoffman AS, Stayton PS. "Hemolytic activity of pH-responsive polymer-streptavidin bioconjugates". Bioconj. Chem. (1999), 10(3), 401-405.

Murthy N, Subramanian U, Anant S, Subramanian KN. "The replication inhibition activity of the WT1 tumor suppressor protein resides in its N-terminal 298 amino acid region, and does not require specific binding of the protein to the replication origin sequence". Int. J. Oncol. (1998), 13(6), 1275-1280.

PUBLICATIONS

2010

2009

2008

2007

2006

2005

pre-2005

Wilson DW, Dalmasso G, Wang L, Sitaraman SV, Merlin D, Murthy N. "Orally delivered thioketal-nanoparticles loaded with TNFα-siRNA target inflammation and inhibit gene expression in the intestines". Nature Materials (2010), 9 (11), 923-928.

Willett N, Kundu K, Knight SF, Murthy N, Taylor WR. "Redox signaling in an in vivo murine model of low magnitude oscillatory wall shear stress". Antioxidants and Redox Signaling In Press (2010).

Dasari M, Lee S, Sy J, Kim D, Lee S, Brown M, Davis M, Murthy N. "Hoechst-IR: An imaging agent that detects necrotic tissue in vivo by binding extracellular DNA". Organic Letters (2010), 12 (15), 3300-3303.

Kundu K, Knight S, Willett N, Lee S, Taylor W, Murthy N. "The kinetic isotope effect significantly improves the efficacy of radical oxidant probes". Angewandte Chemie International (2010), 49 (35), 6134-6138.

Sullivan SP, Koutsonanos DG, Martin MP, Lee JW, Zarnitsyn V, Murthy N, Compans RW, Skountzou I, Prausnitz MR. "Dissolving polymer microneedle patches for influenza vaccination". Nature Medicine (2010) 16, (8), 915-929.

Tang H, Cao W, Kasturi S, Pai R, Nakaya HI, Kundu K, Murthy N, Kepler TB, Malissen B, Pulendran B. "The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling". Nature Immunology (2010), 11 (7), 608-617.

Sy J, Phelps E, Garcia AJ, Murthy N, Davis ME. "Surface functionalization of polyketal microparticles with nitrilotriacetic acid-nickel complexes for efficient protein capture and delivery". Biomaterials. (2010), 31(18), 4987-4994.

Fiore VF, Lofton MC, Roser-Page S, Yang SC, Roman J, Murthy N, Barker TH. "Polyketal microparticles for therapeutic delivery to the lung". Biomaterials (2010), 31(5), 810-817.

Seshadri G, Sy J, Dikhalov S, Murthy N, Davis M. "Delivery of SOD with polyketal particles protects rats from myocardial ischemia-reperfusion injury". Biomaterials (2010), 31(6), 1372-1379.

Lee S, Yang SC, Kao CY, Pierce RH, Murthy N. "Solid polymeric microparticles enhance the delivery of siRNA in vivo". Nucleic Acid Research (2009), 37(22), e145/1-e145/10.

Heffernan M, Murthy N. "Disulfide-crosslinked polyion micelles for delivery of protein therapeutics". Annals of Biomedical Engineering (2009), 37(10), 1993-2002.

Lin P, Myers L, Ray L, Song S, Nasr T, Berardinelli A, Kundu K, Murthy N, Hansen J, Neish A. "Lactobacillus rhamnosus blocks inflammatory signaling in vivo via reactive oxygen species generation". Free Radical Biology & Medicine (2009), 47(8), 1205-1211.

Dasari M, Lee D, Erigala VR, Murthy N. "Chemilumenescent PEG-PCL micelles for imaging hydrogen peroxide". Journal of Biomaterials Research, Part A (2009) 89A (3) 561-566.

Heffernan MJ, Kasturi SP, Yang S, Pulendran B, Murthy N. "The stimulation of CD8+ T cells by dendritic cells pulsed with polyketal microparticles containing ion-paired protein antigen and poly(inosinic acid)-poly(cytidylic acid)". Biomaterials (2009), 30 (5) 910-918.

Kundu K, Knight S, Willett N, Lee S, Taylor W, Murthy N. "Hydrocyanines: A new class of fluorescent sensors that can image reactive oxygen species in cell culture, tissue and in vivo". Angewandte Chemie International (2009), 48 (2), 299-303.

Sy J, Iyer G, Yang S, Brown M, Oh T, Dikalov S, Murthy N, Davis ME. "Sustained release of a p38-inhibitor from non-inflammatory microspheres inhibits cardiac dysfunction". Nature Materials. (2008), 7 (11), 863-868.

Lee D, Erigala VR, Dasari M, Yu J, Dickson RM, Murthy N. "Detection of hydrogen peroxide with chemiluminescent micelles". International Journal of Nanomedicine. (2008), 3 (4) 471-476.

Gongora MC, Lob HE, Landmesser U, Guzik T, Martin WD, Ozumi K, Wall SM, Wilson DS, Murthy N, Gravanis M, Fukai T, Harrison DG. "Loss of extracellular SOD leads to acute lung damage in the presence of ambient oxygen-A potential mechanism underlying Adult Distress Respiratory Syndrome". American Journal of Pathology. (2008) 173 (4) 915-926.

Cao W, Manicassamy S, Tang H, Kasturi S, Pirani A, Murthy N, Pulendran B. "Toll-like receptor mediated type I interferon induction in plasmacytoid dendritic cells requires the rapamycin-sensitive PI3K-mTOR-p70S6K pathway". Nature Immunology. (2008), 9 (10), 1157-1164.

Yang SC, Bhide M, Crispe IN, Pierce RH, Murthy N. "Polyketal Copolymers: A new acid-sensitive delivery vehicle for treating acute inflammatory diseases". Bioconj Chem. (2008), 19 (6), 1164-1169.

Sullivan S, Murthy N, Prausnitz M. "Minimally invasive protein delivery with rapidly dissolving polymer microneedles". Advanced Materials. (2008), 20(5), 933-938.

Chung IM, Enemchukwu NO, Khaja SD, Murthy N, Mantalaris A, Garcia AJ. "Bioadhesive hydrogel microenvironments to modulate epithelial morphogenesis". Biomaterials. (2008), 29(17), 2637-2645.

Lee D, Khaja S, Velasquez CJ, Dasari M, Sun C, Petros J, Taylor W, Murthy N. "In vivo imaging of hydrogen peroxide with chemiluminescent nanoparticles". Nature Materials. (2007), 6(10), 765-769.

Lee S, Murthy N. "Targeted delivery of catalase and superoxide dismutase to macrophages using folate". Biochemical and Biophysical Research Communications. (2007), 360(1), 275-279.

Khaja S, Lee S, and Murthy N. "Acid degradable protein delivery vehicles based on metathesis chemistry". Biomacromolecules. (2007), 8(5), 1391-1395.

Lee S, Yang SC, Heffernan MJ, Taylor WR, Murthy N. "Polyketal microparticles: a new delivery vehicle for superoxide dismutase". Bioconj Chem. (2007), 18(1) 4-7.

Talsma S, Babensee J, Murthy N, Wiliams R. "Development and in vitro validation of a targeted delivery vehicle for DNA vaccines". J. Control. Release. (2006), 112(2), 271-279.

Hao J, Kwissa M, Pulendran B, Murthy N. "Peptide crosslinked micelles: A new strategy for the design and synthesis of peptide vaccines". International Journal of Nanomedicine. (2006), (1), 97-103.

Heffernan M, Murthy N. "Polyketal nanoparticles: A new pH sensitive, biodegradable drug delivery vehicle". Bioconj. Chem. (2005), 16(6), 1340-1342.

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Ning X, Lee S, Wang Z, Kim D, Subbtlefield B, Gilbert E, Murthy N.  “Maltodextrin based imaging probes detect bacteria in vivo with high sensitivity and specificity”.  Nature Materials.  In Press 2011.

Gray W, Che P, Brown M, Ning X, Murthy N, Davis M.  “N-acetylglucosamine conjugated to nanoparticles enhances myocyte uptake and improves delivery of a small molecule p38 inhibitor for post-infarct healing.   J. of Cardiovasc.  Trans.  Res.  In Press 2011.

Selvam S, Kundu K, Templeman KL, Murthy N, García AJ.  “Minimally invasive, real-time imaging of biomaterial-associated inflammation.  Biomaterials.  In Press 2011.

Swanson PA, Kumar A, Samarin S, Vijay-Kumar M, Kundu K, Murthy N, Hansen J, Nusrat A, Neish A. “Enteric commensal bacteria potentiate epithelial restutiion via reactive oxygen species-mediated inactivation of focal adhesion kinase phosphatases”.  Proc. Natl. Acad. Sci.  (2011), 108(21), 8803-8808.

Kasturi SP, Skountzou I, Randy A, Koutsonanos K, Hua T, Nakaya H, Ravindran R, Stewart S, Alam M, Murthy N, Hogan RJ, Sastre A, Compans R, Pulendran B.  “Synergistic TLR activation stimulates persistent germinal centers and long-lived antibody producing cells that protect against avian and swine influenza”. Nature.  (2011), 470 (7335), 543-547. 

2011