Jay C. Sy

Ph.D. Student

Research Area

Jay is a co-advised student with Dr. Michael Davis and Dr. Niren Murthy. His project focuses on improving the treatment of myocardial infarcts using drug delivery vehicles. Due to its unique non-inflammatory properties, Jay is pursuing the use of polyketal microparticles to inhibit inflammatory signaling pathways by delivering small molecule inhibitors as well as using new chemistries to improve protein delivery and particle targeting to cardiac myocytes and stem cells.

Emailmailto:jcsy@gatech.edu?subject=email%20subject

Advanced Materials (in press)
“Emulsion as a means of controlling electrospinning of polymers.” JC Sy, AS Klemm, VP Shastri.

Nature Materials (November 2008, (11):863-868)
“Sustained release of a p38 inhibitor from non-inflammatory microspheres inhibits cardiac dysfunction.” JC Sy, G Seshadri, SC Yang, M Brown, T Oh, S Dikalov, N Murthy, ME Davis.

Analytical Chemistry (2008, 80 (16):6365-6372)
“Microfluidic-Based Cell Sorting of Francisella tularensis Infected Macrophages using Optical Forces.” T Perroud, J Kaiser, JC Sy, T Lane, C Branda, A Singh, K Patel.

Biomaterials (May 2006, 27 (15): 3021-3030)
“Towards development of surface eroding poly(?-hydroxy acids).” X-J Xu, JC Sy, VP Shastri.

Publications

Education/Background

Jay is a co-advised student with Dr. Michael Davis and Dr. Niren Murthy. His project focuses on improving the treatment of myocardial infarcts using drug delivery vehicles. Due to its unique non-inflammatory properties, Jay is pursuing the use of polyketal microparticles to inhibit inflammatory signaling pathways by delivering small molecule inhibitors as well as using new chemistries to improve protein delivery and particle targeting to cardiac myocytes and stem cells.

US Patent Application 60/829,458 (filed October 13, 2006)
"Modulation of drug release from electrospun fibers." VP Shastri, JC Sy, AS Klemm.

US Patent Application 60/619,156 (filed October 15, 2004)
"Nano- and micro-scale engineering of polymeric scaffolds for vascular tissue engineering." VP Shastri, JC Sy.

US Patent Application 60/556,637 (filed March 25, 2004)
"Emulsion-based control of electrospun fiber morphology." VP Shastri, JC Sy, I-W Chen.

Patents

Materials Research Society Fall Meeting 2008
“IMAC functionalization of polyketal microparticles for dual mode drug release” JC Sy, N Murthy, ME Davis.

Society for Biomaterials Translational Research Symposium 2008
“Nitrilotriacetic acid-nickel affinity protein delivery via polyketal microparticles.” JC Sy, N Murthy, ME Davis.
*Student Travel Achievement Recognition Award, Honorable Mention

236th American Chemical Society National Meeting 2008
“Immobilized metal-affinity protein delivery.” JC Sy, N Murthy, ME Davis.

American Heart Association Council on Basic Cardiovascular Sciences 2007
“Encapsulation of a small molecule p38 inhibitor for cardiac regeneration.” JC Sy, G Iyer, S Dikalov, N Murthy, ME Davis.
*Finalist for Outstanding Early Career Award (1 of 3 selected)

Biomedical Engineering Society Fall Meeting 2006
“Release of bioactive agents from nanofibers meshes electrospun from emulsions.” JC Sy, AS Klemm, VP Shastri.

Biomedical Engineering Society Fall Meeting 2004
“Nano- and micro-scale engineering of synthetic vascular grafts.” JC Sy and VP Shastri.
*Podium presentation

Publications

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